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Research Archive

Explore scientific data on both our Next Generation and traditional tobacco portfolios. Use the filters below to narrow things down, or simply search via keyword. Scroll down to explore scientific data.

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Scientific Assessment Area

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Multiple Endpoint In Vitro Toxicity Assessment of a Prototype Heated Tobacco Product Indicates Substantially Reduced Effects Compared to Those of Combustible Cigarettes

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Key Challenges for In-Vitro Testing of Tobacco Products for Regulatory Applications – Recommendations for Dossimetry

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A Survey of Aerosol Exposure Systems Relative to the Analysis of Cytotoxicity (CORESTA 2022)

Key Challenges for In-Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for Dosimetry

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Perceptions of the Relative Harm of Electronic Cigarettes Compared with Combustible Cigarette in the USA

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Analysis of Selected Organic Acids in E-Liquids by Ion Chromatography

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Analysis of Glycidol in E-Vapor Products

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Analysis of Aromatic Aldehydes in E-Vapor Products

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Assessing the US population health impact of a new e-cigarette product in to a market using intentions to use data

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Comparison of heated tobacco product aerosol to cigarette smoke in human bronchial epithelial tissue using High Content Screening

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Key challenges for in vitro testing of tobacco products for regulatory applications

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Examination of the Impact of myblu Electronic Nicotine Delivery System E‐liquid Strength on Self-Reported Measures of Dependence

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A clinical study to evaluate the pharmacokinetic, pharmacodynamic and safety and tolerability profiles of tobacco‑free oral nicotine pouches relative to cigarettes

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E-Cigarette Aerosol Deposition and Disposition of Nicotine using Positron Emission Tomography

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Use of a Rapid Human Primary Cell-Based Disease Screening Model to Compare NGPs to Combustible Cigarettes

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Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products

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Preclinical Assessment of Tobacco-Free Nicotine Pouches Demonstrates Reduced In Vitro Toxicity Compared with Tobacco Snus and Combustible Cigarette Smoke

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The Importance of Dosimetry (Institute for In Vitro Sciences)

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THR in Medicine and Public Health ESMED

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Reductions in biomarkers of exposure to selected harmful and potentially harmful constituents following exclusive and partial switching from combustible cigarettes to myblu (CORESTA 2021)

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Substantial reductions in selected harmful and potentially harmful constituents in heated tobacco aerosol, compared to 1R6F reference cigarette smoke (CORESTA 2021)

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Assessment of alternative human derived cell lines with the OECD TG 129 for cytotoxicity determination (CORESTA 2021)

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Assessing the impact of NGP on population health – a population model approach (CORESTA 2021)

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Risk perceptions and likelihood of use of nicotine pouches among current, former and never nicotine users (CORESTA 2021)

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Examination of the impact of e-liquid nicotine strength on perceived dependence on myblu ends (TSCR 2021)

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Curiosity and intentions to use myblu ends and an examination of the gateway theory data from cross sectional nationally representative surveys (TSCR 2021)

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The Science of Heated Tobacco: Risk Perceptions and Intention to Use Pulze

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Analysis of the 2020 U.S. NYTS – Vaping and blu Use Among Middle and High School Students

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Use of a rapid human primary cell-based disease screening model to compare NGPs to combustible cigarettes

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Reductions in Biomarkers of Exposure to Selected HPHCs Following Exclusive and Partial Switching from Combustible Cigarettes to myblu™ vape

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A Survey of Aerosol Exposure Systems Relative to the Analysis of Cytotoxicity – A CORESTA Perspective

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Reduced Levels of HPHCs in HT Aerosol Translates to Reduced In Vitro (Geno)Toxicological Outcomes

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Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke

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Imperial Brands’ Nicotine Pouches – A Promising Tobacco Harm Reduction Product for Adult Smokers

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Assessing the Relative In Vitro Genotoxic Potential of E-Liquids and their Aerosols – the ToxTracker and Aneugen Clastogen Evaluation Assay

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Multi-Endpoint Analysis of Human 3D Airway Epithelium Following Repeated Expsoure to Whole Vape Aerosol or Cigarette Smoke

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An Interlaboratory In Vitro Aerosol Exposure System Reference Study

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Human Lung Tissue Exposure to Acute Vape Aerosol Results in Minimal Cellular and Transcriptomic Responses Compared to Combustible Cigarettes

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An In Vitro Genotoxicity Assessment for Next Generation Nicotine Delivery Products – Industrial Genotoxicology Group (IGG) Virtual AM 2020

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Reduced Developmental Toxicity Potential of Non-Combusted Products Compared to Cigarettes – Screening with Human Induced Pluripotent Stem Cells

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Collecting E‐Cigarette Aerosols for In Vitro Applications: A Survey of the Biomedical Literature and Opportunities to Increase the Value of Submerged Cell Culture‐based Assessments

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What is Nicotine? (Infographic)

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Perception of the Relative Harm of Vapes Compared to Cigarettes Amongst US Adults from 2013 to 2016: Analysis of the PATH Study Data

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A Comparative In Vitro Toxicity Assessment of Vaping E-liquids and Aerosols with Tobacco Cigarette Smoke

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Beyond Smoke: Talking Tobacco Harm Reduction Infographic

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Workshop Recommendations for Use of In Vitro Assay Data for Tobacco Product Evaluation: Phase 1 – Genotoxicity

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blu – The Science of Something Better

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Aerosol Concentration Variations in a Room During Use of an E-cigarette

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Why Flavours Play an Important Role in Vaping

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Vaping and Public Health

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The Science of Nicotine and Vaping

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E-liquids and Product Standards

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Vaping is not a Gateway to Smoking

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Vaping and Dual Use

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Flavours – Something Better is Something Different

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Toxicant Exposure – Vaping vs Smoking

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The Science of “Passive Vaping”

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An Introduction to the Science of Vaping

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Nicotine Salts Can Help Adult Smokers Move Toward Vaping

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Glasgow 90-Day Clinical Vaping Study

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Lab Tests Suggest Human Lung Tissue Unimpacted by Vapour

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Lab Tests Suggest Vapour Does Not Disrupt Endothelial Cell Migration

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Vapour – Shows No Evidence of Damage to Lung Cells

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Nicotine Salts Help More Adult Smokers Transition to Vaping

Snus – The Original Reduced Harm Product

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Heated Tobacco – The Anatomy of Something Better

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Introducing Tobacco-Free Oral Nicotine Delivery

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Vapour – The Anatomy of Something Better

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NGP Flavours – Something Better is Something Different

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Chemical Composition and In Vitro Toxicity Profile of a Pod-Based E-Cigarette Aerosol Compared to Cigarette Smoke

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ST20: Responsible Practice in EVP Product Stewardship

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An Inter-Laboratory Comparison for a Urinary Acrolein Biomarker

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Analysis of the Effect of Multiple Testing in Assessing Tobacco Product Differences

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Physical characteristics of handmade premium cigars : specifications and consequences of specifications

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An in-vitro approach to EVP toxicity testing

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Nicotine Reduction and Consumer Perception – A Scientific Approach for Quantifying Possible Impact of LNC

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Nicotine Salts Help More Adult Smokers Transition to Vaping

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NGPs Induce Lower Biological Activity than Cigarettes Using BioMAP® System of Human Primary Cell Based Co-Cultures

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Which Parameters are Suitable to Evaluate EVP Puffing Behaviour?

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Method for Analysis of Volatile Organic Compounds in EVP Aerosol Based on Proton Transfer Reaction Mass Spectrometry

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Estimation of EVP Aerosol Yields based on Puff Duration

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Consistency of blu EVP Nicotine Delivery According to the AFNOR Standard

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Chemical Composition of blu Pod-System EVP Aerosols – A Quantitative Comparison with Conventional Cigarette Smoke

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Chemical Characterisation of Aerosol Emissions from a Prototype Heated Tobacco Product

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Real-time Analysis of EVP Aerosol Constituents Using PTR-MS

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Indoor Air Quality and Exhaled Breath Composition After Use of Nicotine Delivery Products

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Experimental Method to Determine Concentration of Nicotine in Exhaled Breath and Retention Rate Following EVP Use

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Smoking Reduction and Cessation Associated with the Three-Month Provision to Smokers of a Refillable Tank-Style E-Cigarette

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Perceptions of the Relative Harm of Electronic Cigarettes Compared with Smoking in the USA

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Analysis of the Data Variability in the Australian Benchmark Study 2000-2001

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Misperception of EVP Harm Growing Among American Adults, 2013-2015

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EVPs: An Assessment of the So-Called ‘Gateway Effect’ Based on Product Classification

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Changing Patterns of First EVP Flavour Used and Current Flavors Used by 20,836 Adult Frequent EVP Users in the USA

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[UPDATE] Perceptions of the Relative Harm of Electronic Cigarettes Compared with Smoking in the USA

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Parameters Influencing Bystander Exposure to Nicotine in the Indoor Ambient Air During Use of an EVP

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Modelling of the Effect of Indoor Intermittent Emissions Produced by Electronic Cigarette Users on Exposure of Bystanders

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Indoor Air Quality and Surface Deposition Assessment following Use of an Open System E-Cigarette

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Electronic Cigarettes and Indoor Air Quality: A Simple Approach to Modeling Potential Bystander Exposures to Nicotine

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Characterisation of Spatial and Temporal Dispersion Differences Between Exhaled EVP Vapour and Cigarette Smoke

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Bystander Exposure to Exhaled EVP Vapour Assessment of Nicotine in Ambient Air Using Modelling & Experimental Approach

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An Assessment of Nicotine Levels on Office Surfaces Before and After Use of EVPs

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An Assessment of Indoor Air Quality Before, During and After Unrestricted Use of EVPs in a Small Room

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An Assessment of Indoor Air Quality Before, During and After Unrestricted Use of EVPs in a Small Room

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NGPs Predicted to Have No Potential to Induce Developmental Toxicity in the DevTOX QuickPredict Assay

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The Use of Genomic Allergen Rapid Detection (GARD) Assays to Predict the Respiratory and Skin Sensitising Potential of E-liquids

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E-Liquids – An Assessment of Dermal Irritancy Potential

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Analytical Method to Model Human Mouth Level Transfer of Ingredients from Snus

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Snus: A Compelling Harm Reduction Alternative to Cigarettes

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Human Mouth-Level Transfer Rate of Menthol, 1.8-cineole and Nicotine from Swedish Pouched Snus

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Use of Human 3D Bronchial Tissue to Study the Effects of Cigarette Smoke and EVP Aerosol on a Range of Cellular Endpoints

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Toxicological Comparison of Cigarette Smoke and EVP Aerosol Using a 3D In Vitro Human Respiratory Model

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The In Vitro Assessment of Respiratory Sensitisation Potential of E-Liquids

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Influence of Vaping Topography on the Retention Rate of Nicotine

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High Content Screening in NHBE Cells Shows Reduced Biological Activity of Flavoured E-liquids, Compared to Cigarette Smoke

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EVPs Induce Lower Biological Responses than Cigarettes – Toxicity Comparison of Aerosol Exposure to Human Bronchial Tissue

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A Comparison of In Vitro Toxicity Following Repeated Whole Aerosol Exposure to Human Bronchial Tissue for 4 Weeks

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Cardiovascular and Pulmonary Function Endpoints and Other Effects – EVP vs. Cigarettes in Adult Smokers

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NGP vs. Cigarettes Comparison of In Vitro Cell Migration in the Scratch Wound Assay

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Reductions in BoE to HPHCs Following Partial or Complete Substitution of Cigarettes with EVPs

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Clinical Study Evaluating the Reduction in HPHCs Following Partial or Complete Substitution of Cigarettes with EVPs

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Evaluation of the Safety Profile of an EVP Used for Two Years by Smokers in a Real-Life Setting

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Biomarkers of Exposure and Cardiovascular & Pulmonary Function Endpoints in Adult Smokers Using EVPs

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A Randomised, Parallel Group Study to Evaluate the Safety Profile of an EVP Over 12 Weeks

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Toxicological Comparison of Cigarette Smoke and NGP Aerosol Bubbled Extracts Using High Content Screening

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NGP Aerosol Induces Lower Biological Activity than Cigarettes – Comparison of Aerosol Bubbled Extracts

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NGP Aerosol Bubbled Extracts Show Little to No Effect in High Content Screening Endpoints Compared to Smoke

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Use of In Vitro Biomarkers From Relevant Primary Cell Systems to Assess the Effects of Experimental and Commercial E-liquid

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Use of High Content Screening (HCS) in Human Primary Lung Cells to Assess E-liquids

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Use of Cell Media Nicotine Concentration to Predict Cells Surface Deposited Nicotine in Transwells After Smoke Aerosol Exposure

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QRA Indicates Reduced Risk Potential for Carcinogenic and Non-carcinogenic Effects of NGP Aerosol Compared to Smoke

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Pre-Clinical Assessment of a Dual-Temperature Operated Heated Tobacco Device

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NGPs Induce Lower Biological Activity Than Cigarettes – Comparison of Aerosol Chemistry and In Vitro Toxicity

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Influence of Vaping Topography on the Retention Rate of Nicotine Following Use of EVP

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Assessing Changes In Biomarkers Of Effect In Smokers Who Switch To A Closed System EVP

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Clinical Study Evaluating the PK Profiles of Cigarettes and EVPs with Nicotine Salt Formulations in US Adult Smokers

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Viral Infection and Nicotine Conversion to Nornicotine in the Next Generation

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Using a Structural Model based on a Class of Generalised Covariance Criteria, to Explore the Generation Process of Smoke Compounds

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Use of Molecular Markers Related to Quality Improvement of Tobacco Plant

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Use of Human Derived Cell Lines to Increase the Biological Relevance of Cigarette Condensate, Non-Tobacco Materials and E-liquids Testing

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TSNAs in Tobacco and Smoke – PLS Regression for Prediction of Smoke Contents According to Chemical and Physical Characteristics

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Tobacco Smoke – Chemical and Physical Properties and Toxicity

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Tobacco Cultivars Evolution in France (1989-2006) and Impact to the Raw Matter

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Tobacco Characteristics – AMES test

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Tobacco Breeding Program of Bergerac Tobacco Institute – Methods, Results and Future Prospects

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The UK Smoke Constituents Testing Study – Summary of Results and Comparison with Other Studies

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The Regulation and Governance of Residues of Plant Protection Products

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The PVY Collaborative Experiment (1996-2002) – A Global Synthesis of Results

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The Protection of Tobacco Varieties with the UPOV System in EU

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The Influence of Cigarette Design on the Ageing of Carbon Filters

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The Food and Drug Administration Predictive Toxicology Roadmap and its Implementation

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The European Tobacco Product Directive and E-cigarette Compliance – a Test Method for Drop Testing of E-liquid Bottles

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The Effect of Charcoal Filters on Gas Vapour Phase In Vitro Toxicity Tested in Different Air and Liquid Interface Exposure Systems

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The Application of In Vitro Toxicity Testing in 21st Century (TT21C) for Next Generation Products

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Targeted Mutation Breeding as a Tool for Tobacco Crop Improvement

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Strategies to Assess the Biological Properties of Tobacco Smoke

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Smoke Analysis of Fine-Cut Tobacco (Part 3)

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Simple and Reliable Method for the Quantification of Proteins in Tobacco

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Sensory Quality Control by Electronic Nose in Manufacturing Plants

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Seed Quality Management as a Component of Tobacco Identity Preservation

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RNA-SEQ Analysis of Orobanche Resistance in Tobacco

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Responsible Practice in E-Vapour Products (EVP) Product Stewardship

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Responsible Practice in E-Vapour Products (EVP) Product Stewardship (2)

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Resistances to the Tobacco Cyst Nematode Complex in Nicotianae

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Recent Improvements in In Vitro Models Need to be Supported with Refinements in Dosimetry to Enable Possible Future In Vivo Data Extrapolation

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Real-time Gas Phase Puff-by-Puff

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Rapid and Sensitive Method to Analyse β-carbolines, Norharman and Harman in Cigarette Smoke

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Quantitative Risk Assessment (QRA) vs. the Whole Story

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Prospects for Orobanche Control in Tobacco

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Prediction of a Biological and a Chemical Variable According to the Tobacco’s Chemical and Physical Characteristics

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Potential Use of HMA Mutants to Reduce Cadmium Translocation from Root to Leaf in Tobacco

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Potential Changes of TSNA Composition in Stored Tobacco Powder

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Patenting Plants – New Challenges

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Overview of In Vitro Methods to Assess Electronic Nicotine Delivery Systems Based on TT21C Principles

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Nitrogen Compounds on Mainstream Smoke and Tobacco Precursors

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Near-infrared Spectroscopy and Pattern Recognition as Screening Methods for Classification of Commercial Tobacco Blends

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Mutagenicity of Cigarette Smoke Vapour Phase in the AMES Test

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Modeling of Cigarette Smoke Constituents – From Intense to Less Intense Smoking Regime

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Methodologies for the Detection and Chemical Characterisation of Particles Released from Cigarette Filters

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Mechanisms of Transfer of Ammonia in Smoke from Ammonium Compounds in Tobacco

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Lowering Nicotine Levels in Tobacco Products

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Investigation of Filter Temperatures and Desorption of Volatiles from Carbon Filters Under Different Smoking Regimes

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Influence of the Origin of the Cigarette Paper Cellulose on the Chemical Composition of the Smoke and In Vitro Toxicity Test

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Influence of Cigarette Paper and Filter Ventilaton on Hoffman Analytes

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Influence of Cigarette Designs and Smoking Regimes on Vapour Phase Yields

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In Vitro Tests with Fresh Cigarette Smoke – Effects of Charcoal Filters on Whole Smoke and Vapour Phase Mutagenicity and Genotoxicity

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In Vitro Cytotoxicity of Cigarette Mainstream Smoke. Evaluation of Different Cell Exposure Methods

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Impact of PVYN Infection on Burley Cigarette Smoke Condensate Properties – An Assessment of the Protection Conferred by the VA Gene

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IMB Response to UK Science and Technology Committee Enquiry on E-cigarettes

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How Representative of Human Smoking Behaviour Would New Alternative Smoking Regimes Be

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Hoffmann Analytes and Cigarette Smoke In Vitro Toxicity – Revisited

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Hoffmann Analytes – Influence of Cigarette Paper and Filter Ventilation

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High Throughput Puff-By-Puff Quantification of Smoke Analysis

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HCN and Tobacco Precursors

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Hard Science as a Basis for Effective Regulations

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Handmade Premium Cigar Smoke Emissions Limitations Related to TNCO Determination Variability

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Further Investigation of Temperatures and Adsorption-Desorption of Volatile Compounds in Carbon Filters Under Different Smoking Regimes

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Further Data on Cigarette Temperatures and Related Issues

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Free Radicals in Mainstream Cigarette Smoke Methodology and Influencing Parameters

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Fingerprints of Tobacco Smoke Precursors by Comprehensive GCxGC

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Fine-Cut Tobacco Annual TNCO Study using a Monitor Tobacco

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Fast and Simple Method for the Determination of Urinary 1-Hydroxypyrene

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Factors Influencing the Formation of Tobacco-Specific Nitrosamines in French Air-Cured Tobaccos in Trials and at the Farm Level

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Evolutionary Pathways of Potato Virus Y

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Evaluation of Tobaccos Grown Under Organic Cultural Practices

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Effects of Filter Ventilation and Activated Carbon Filters on Cigarette Smoke Constituent Uptake

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Effect of Sugar Content on Acetaldehyde Yield in Cigarette Smoke

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Effect of Smoking Regime on Activated Carbon Desorption

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Effect of Smoking Parameters on the Temperature in Cigarette Filters During Smoking

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Draw Resistance During Smoking

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Determination of Menthol in Cigarette Components by GC

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Determination of Hoffmann Analytes in Cigarette Smoke

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Determination of Amadori Compounds in Tobacco by Ion Pair Chromatography Coupled to Electrochemical Detector – the Latest Improvements

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Detection of QTLs Linked to Leaf and Smoke Properties in Nicotiana Tabacum

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Current Reliability of Measurements of Smoke Analytes

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Current Measurement Reliability of Selected Smoke Analytes

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The Risk Continuum

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Plenary Presentation Building Trust – Science and Innovation

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Limitations in the Characterisation of Cigarette Brands Using Different Machine Smoking Regimes

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Determination of Selected Volatiles in Cigarette Smoke

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Determination of Aromatic Amines in Cigarette Mainstream Smoke

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ASR Yield Variability Under Different Regimes

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Biological Test Procedure for Fresh Generated Smoke and Aerosols

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Contribution of Near Infrared Spectrometry (NIRS) to Tobacco Breeding

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Contribution of Genomic Research to Develop Disease Resistance in Tobacco

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Construction of a Genetic Map of Nicotiana Tabacum

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Compensation for the Effects of Ambient Conditions on the Calibration of Multi-Capillary Pressure Drop Standards pt2

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Compensation for the Effects of Ambient Conditions on the Calibration of Multi-Capillary Pressure Drop Standards pt3

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Compensation for the Effects of Ambient Conditions on the Calibration of Multi-Capillary Pressure Drop Standards

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Comparison of Tobacco Extracts – A Strategy Based on GCXGC-MS Analysis and Chemometric Data processing

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Comparison of Regular Smokers of Menthol and Non-Menthol Cigarettes on Smoking Profile and Exposure

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Comparison of In Vitro Smoke Toxicity of Novel Charcoal Filter Cigarettes and Benchmark Cigarettes from the UK market

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Comparison of Different Clean-Up Procedures for the Determination of Plant Protection Products in Tobacco and Tobacco Products by lC-MSMS

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Chemical Changes in Cigarette Smoke Mutagenicity Associated with CMVPVY Infection in Burley Tobacco

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Characterisation of the Draw Resistance Across a Lit Cigarette

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Characterisation of PVY (Potato Virus Y) Resistance in Tobacco

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Characterisation of French and Brazilian PVY Isolates from Susceptible or Resistant Tobacco Plants

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Characterisation of Cigarette Hardness and Tobacco Filling Power

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Cellular Transformation Activity of Different Tobacco Products in the Bhas42 Cell Assay

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Building blu – Harm Reduction Science

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Biological Test Procedure for Fresh Generated Smoke and Aerosols

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Biological Assessment of Cigarette Whole Smoke

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Assessment of Smokers’ T&N Yields

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Assessment of Smokers’ T&N Yields Under Natural Smoking Conditions

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Assessment of Flue-cured and Burley Breeding Progress in France

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Applications of Near Infrared Reflectance Spectroscopy to Quantitative and Qualitative Characteristics of Tobacco Blends

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Application of Near Infrared Spectroscopy to Tobacco Plant Breeding

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Application of a Modal Reactor for Efficiency Testing of Potential Filter Additives

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Application of 13C Tracer Technique to Study Fate and Behaviour of Ingredients Applied on Tobacco

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Analysis of Pesticides in Tobacco by LC-MSMS Specific Matrix Effects on Quantification for Different Tobacco Grades

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Analysis of 16 Amino Acids in Tobacco by Ion Pair LC ESI MS MS without Derivatisation

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An Overview of Toxicity Testing in 21st Century (TT21C) – In Vitro Methods to Assess Next Generation Products

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An International Survey of Indoor Air Quality, Ventilation and Smoking Activity in Restaurants

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An Alternate Strategy of Risk Reduction for Tobacco Smokers

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Airflow Characterisation within a Cigarette using a Permeability Meter

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Agrobacterium T-DNA in N. tomentosiformis and other Nicotiana Species

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A New Device for Firmness Characterisation

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A Mixture Experimental Design with 6 Components and the Effects on Smoke Constituents

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A Comprehensive Survey of the N. Tabacum Transcriptome

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